Dermpath Made Simple Neoplastic Spitz Nevus and Reed Nevus

Dermoscopy of Pigmented Spitz and Reed Nevi The Starburst Pattern Dermatology JAMA

However, to date, many textbooks or atlases of dermatology or histopathology assert that Reed nevus is a variant of Spitz nevus [4,6,21-25]. According to Argenziano et al, a dermatopathologic distinction between pigmented Spitz and Reed nevus is difficult, not reproducible and maybe clinically useless.

Clinical features and natural history of SpitzReed nevus in children. Semantic Scholar

Differential diagnosis of Spitz and Reed naevi. The differential diagnosis of Spitz and Reed naevi includes acquired melanocytic naevi, blue naevi and melanoma.. Spitz tumours with kinase fusions. It has recently been shown that spitzoid neoplasms harbour kinase fusions of ROS1 (17%), NTRK1 (16%), ALK (10%), BRAF (5%) and RET (3%) in a mutually exclusive pattern.

Dermoscopy Made Simple Reed Nevus

In contrast to Spitz nevus, the indicators of a congenital origin of Reed nevus are poor. The outstanding reports on agminated or systematized Reed nevi, or Reed nevus as constituent of a combined nevus, rather suggest a histogenetic event compatible with what is regarded to be a truly acquired melanocytic nevus and might represent another clue.

Figure 1 from Pigmented Spindle Cell Nevus of Reed of the Eyelid Semantic Scholar

Pigmented spindle cell nevus (PSCN) of Reed is a morphologic variant of Spitz and may be very diagnostically challenging, having histologic features concerning for melanoma. Their occurrence in younger patients, lack of association to sun exposure, and rapid early growth phase similar to Spitz nevi suggest fusions may also play a significant.

Pigmented Spindle Cell Nevus of Reed Dermatopathology

Pigmented spindle cell nevus is a benign melanocytic lesion that was initially described in 1975 by Reed et al. It is generally found on the trunk or lower extremities of young women. Most authors consider it to be a variant of Spitz nevus. The main concern with these lesions remains their propensity to mimic melanoma both clinically and histologically.

Dermoscopy of Pigmented Spitz and Reed Nevi The Starburst Pattern Dermatology JAMA

Reed nevus is considered a pigmented variant of Spitz nevus. It usually appears during childhood, adolescence or early adulthood, and commonly appears on the lower limbs of female patients. After 6 months of rapid growth, Reed nevus tends to show no more enlargements over time. The starburst pattern is the dermatoscopic hallmark of Reed nevus.

Starburst dermoscopic pattern of Reed nevus Download Scientific Diagram

'Nevus, Reed' published in 'Dermatopathology' Pigmented spindle cell nevus is a sharply demarcated and symmetrical melanocytic lesion characterized by a florid and cellular junctional component and marked melanin pigmentation (Fig. 1).The junctional aspect is composed of large and prominent nests containing uniform, spindled melanocytes arranged in fascicles with a characteristic vertical.

Evolution of Reed Nevi Dermoscopic Pattern in Childhood Dermatology JAMA Dermatology JAMA

The Spitz naevus (syn. spindle cell naevus, epithelioid cell naevus, juvenile melanoma) is a variant of a compound naevus and is most commonly seen in children . The pigmented spindle cell naevus of Reed (PSCNOR) is a variant of a compound or occasionally a junctional naevus. There is debate as to whether the PSCNOR is an entity in its own.

Dermpath Made Simple Neoplastic Spitz Nevus and Reed Nevus

Symmetric with cytologic maturation. Nests and fascicles of spindled melanocytes along dermoepidermal junction and within dermal papillae. May be junctional or compound. Expansive, not infiltrative growth pattern. Extends no deeper than reticular dermis. Nevus cells typically contain abundant melanin pigment, may be associated with melanophages.

Dermpath Made Simple Neoplastic Spitz Nevus and Reed Nevus

Spitz naevus is classified as classic, pigmented, or spindle cell tumour of Reed. The classic Spitz naevus is typically a dome-shaped red, reddish-brown papule. A pigmented Spitz naevus is a tan or brown papule or nodule. A pigmented spindle cell tumour of Reed is a bluish or black papule. There are clinical features in common for all three.

Reed Nevus (Pigmented Spindle Cell Nevus) in an 11MonthOld Japanese Infant

The clinical-dermatoscopic-histological correlation of excised Spitz/Reed nevi revealed overlapping histopathological features among lesions displaying distinct dermatoscopic patterns ( Figures 1 - 3 ). Among lesions with histopathological atypia (16/47, 34.0%), all dermatoscopic patterns were represented, although the atypical/multicomponent.

Reed nevus on the finger (A) Clinical features of the lesion. (B)... Download Scientific Diagram

Reed nevus is composed histologically of elongated spindle-shaped and nevoid cells with a benign biologic behavior. Histopathological features in common with Spitz nevi and in contrast with malignant melanoma include a relatively small size, lesion symmetry, uniformity of cell type, good circumscription, and maturation of cells from superficial.

Pigmented Spindle Cell Nevus of Reed Dermatopathology

A Reed nevus is a dark brown or black, raised, dome-shaped mole that most often affects women. These moles can grow quickly and may be mistaken for melanoma. These moles can grow quickly and may.

Dermatoscopic patterns of Reed nevus. Starburst pattern in which black,... Download Scientific

Update on dermoscopy of Spitz/Reed naevi and management guidelines by the International Dermoscopy Society Br J Dermatol. 2017 Sep;177(3):645-655. doi: 10.1111/bjd.15339.. Nevus, Epithelioid and Spindle Cell / pathology Nevus, Epithelioid and Spindle Cell / therapy*.

Pigmented Spindle Cell Nevus of Reed Dermatopathology

Clinically, pigmented Spitz/Reed nevi are brown to black, flat to slightly elevated, symmetrical lesions showing a relative preference for certain locations, including face, limbs and buttocks. The most relevant and peculiar feature is the starburst pattern seen by dermoscopy. This is typified by multiple streaks of pigmentation or large.

Naevus van Reed (pigmented spindle cell nevus)

The Reed Nevus or pigmented spindle cell nevus (PSCN) was first described by Reed et al. in 1975 . Its designation as a separate entity vs. a SN variant remains controversial, but is currently considered by the 2018 WHO Classification to be a "distinct variant of Spitz naevus.".